منابع مشابه
[Antiphospholipid antibodies and antiphospholipid syndrome: diagnosis and management].
Antiphospholipid syndrome is an acquired autoimmune thrombophilia that produces significant morbidity and mortality. Its diagnosis requires the presence of antiphospholipid antibodies and clinical manifestations that include thrombotic phenomena and/or recurrent miscarriages. Antiphospholipid antibodies may be detected in many instances, including healthy subjects. Clinical manifestations are v...
متن کاملManagement of the antiphospholipid syndrome: new approaches
Antiphospholipid syndrome (APS) is an autoimmune and multisystem disorder of thrombosis and pregnancy loss, associated with the persistent presence of antiphospholipid (aPL) antibodies [1–3]. These antibodies are directed against protein antigens that bind to anionic phospholipids, such as b 2 glycoprotein I (b 2 GPI) and prothrombin. Thrombosis is the major manifestation in patients with APS, ...
متن کاملDiagnosis and management of the antiphospholipid syndrome.
Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy complications in the presence of persistent antiphospholipid antibodies (APLA). Laboratory diagnosis of APLA depends upon the detection of a lupus anticoagulant, which prolongs phospholipid-dependent anticoagulation tests, and/or anticardiolipin (aCL) and anti-β2-glycoprotein-1 (β2GPI) antibodies. APLA are primarily...
متن کاملClinical Management of Antiphospholipid Syndrome-Related Thrombosis
There is evidence that the presence of antiphospholipid antibodies is related with an increased risk of thrombotic events. Patients with definite antiphospholipid syndrome (APS) and a first venous event should receive long term oral anticoagulation to an international normalized ratio (INR) of 2.0-3.0. In patients with definite APS and arterial or recurrent thrombosis oral anticoagulation to an...
متن کاملThe management of stroke in antiphospholipid syndrome.
Ischemic stroke is one of the most common complications of the antiphospholipid syndrome (APS). Because of the relative lack of definitive prospective studies, there is still some debate as to whether the persistent presence of antiphospholipid antibodies (aPLs) increases the risk of recurrent stroke. There is more evidence for aPLs as a risk factor for first stroke. The mechanisms of ischemic ...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Musculoskeletal Disease
سال: 2010
ISSN: 1759-720X,1759-7218
DOI: 10.1177/1759720x10365969